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- * Ribosomal protein L23 signature *
- ***********************************
-
- Ribosomal protein L23 is one of the proteins from the large ribosomal subunit.
- In Escherichia coli, L23 is known to bind a specific region on the 23S rRNA;
- in yeast, the corresponding protein binds to a homologous site on the 26S rRNA
- [1]. It belongs to a family of ribosomal proteins which, on the basis of
- sequence similarities [2,3,4], groups:
-
- - Eubacterial L23.
- - Archaebacterial L23.
- - Algal and plant chloroplast L23.
- - Fungi L25.
- - Mammalian L23A.
- - Yeast mitochondrial YmL41 (gene MRPL41 or MRP20).
-
- As a signature pattern, we selected a small conserved region in the C-terminal
- section of these proteins, which is probably involved in rRNA-binding [2].
-
- -Consensus pattern: [RK](2)-[AM]-[IVFYT]-[IV]-[RKT]-L-[STANQK]-x(7)-[LIVMF]
- -Sequences known to belong to this class detected by the pattern: ALL, except
- for yeast mitochondrial YmL41.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / Pattern and text revised.
-
- [ 1] El Baradi T.T.A.L., Raue H.A., van de Regt C.H.F., Verbree E.C.,
- Planta R.J.
- EMBO J. 4:210-2107(1985).
- [ 2] Raue H.A., Otaka E., Suzuki K.
- J. Mol. Evol. 28:418-426(1989).
- [ 3] Fearon K., Mason T.L.
- J. Biol. Chem. 267:5162-5170(1992).
- [ 4] Otaka E., Hashimoto T., Mizuta K.
- Protein Seq. Data Anal. 5:285-300(1993).
-